염증성 치근단낭종의 소견을 보이는 이형성 치성낭종
Dysplastic Odontogenic Cyst with the Manifestation of Inflammatory Radicular Cyst
Takashi Muramatsu, 유미현, Sadamitsu Hashimoto, 이상휘, 김진, Masaki Shimono,
소속 상세정보
( Takashi Muramatsu ) - 동경치과대학 구강병리학교실
유미현 ( Ryu Mi-Heon ) - 부산대학교 치의학전문대학원 구강병리학교실
( Sadamitsu Hashimoto ) - 동경치과대학 구강병리학교실
이상휘 ( Lee Sang-Hwy ) - 연세대학교 치과대학 구강악안면외과학교실
김진 ( Kim Jin ) - 연세대학교 치과대학 구강병리학교실
( Masaki Shimono ) - 동경치과대학 구강병리학교실
KMID : 0829220110350030195
Abstract
This report describes a case of odontogenic cyst with keratinization and dysplastic change of lining epithelium, which showed the manifestation of inflammatory radicular cyst, clinically. A 28-year-old man complained of dull pain in the right mandibular molar region. Radiographically a well-defined oval cystic lesion with non-vital teeth, a common finding in radicular cyst, was observed. Microscopically, the lining epithelium of the cyst demonstrated both keratinization and severe epithelial dysplasia. Atypical findings such as hyperchromatic nuclei, increase of N/C ratio and drop shaped rege ridge were observed in the lining epithelium. However, definite invasion into fibrous connective tissue was not found. Immunohistochemically, the dysplastic lining epithelium was highly positive for proliferative marker, Ki-67. Based on the dysplastic changes of lining epithelium, this periapical lesion would be considered to be signs of malignant change. From this case, we conclude that definitive diagnosis by microscopical examination should be made, even if the periapical lesion would be clinically considered as inflammatory radicular cyst.
키워드
Epithelial dysplasia; Odontogenic keratocyst; Radicular cyst
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